Description:
(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is a key intermediate for the synthesis of irinotecan and camptothecin analogues. It is also an ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
- Molecular Weight: 263.25
- Molecular Formula: C13H13NO5
Purity: ≥95%
Canonical SMILES:
CCC1(C2=C(COC1=O)C(=O)N3CCC(=O)C3=C2)O
InChI:
InChI=1S/C13H13NO5/c1-2-13(18)8-5-9-10(15)3-4-14(9)11(16)7(8)6-19-12(13)17/h5,18H,2-4,6H2,1H3/t13-/m0/s1
InChIKey: IGKWOGMVAOYVSJ-ZDUSSCGKSA-N
- Boiling Point: 666.6±55.0 °C at 760 mmHg
- Melting Point: 177.1-178.3 °C
- Appearance: Light Yellow Solid
- Storage: Store at 2-8 °C
Synonyms:
1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-; (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione; Irinotecan Intermediates (94-5); 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (S)-; (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)trione
More details are to be found on supplier website
